If he is determined to do what he wants to do, he will do so what others think of him．A.

If he is determined to do what he wants to do, he will do so what others think of him．
A. on account of
B. in spite of
C. regardless of
D. in case of

A. on account ofB. in spite of(答案→)C. regardless of D. in case of解析：短语辨析. A．因为B．尽管;不顾 C．不顾;不管, D．万一;假设句意:如果他决定要做他想做的事情,不管别人怎样看他他都会这样做. regardless of表示不去考虑，强调主观;in spite of 表示转折，是尽管的意思.故选C.

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